anti-mouse VEGFR-2/KDR, Agonistic monoclonal antibody Anti-Mouse 100 µg

In stock

Cat-Nr.
mV1001r-m
Size
100 µg
  €790.00

Description / anti-mouse VEGFR-2/KDR, Agonistic monoclonal antibody

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis. The antibody will bind near the ligand binding site of the receptor and has agonistic activity.

More Information

Size 100 µg
Source Rat
Isotype IgG2a
Biological Activity VEGFR-2 activation: This antibody can induce mVEGFR2 phosphorylation in mSENDs at > 1.0 μg/mL.
Clone Nr. (#3D09)
Species Reactivity Mouse
Formulation lyophilized
Buffer PBS
Reconstitution Centrifuge the vial prior to opening. Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with purified mouse VEGFR2 N-terminal fragment (AA N30-200)).
Antigen hVEGFR2 N-terminal fragment (N30-200)
Application WB, IP, IHC, Flk1 activation
Synonyms vascular endothelial growth factor receptor-2 ; KDR; FLK1; CD309; VEGF receptor 2; kinase insert domain protein receptor
Uniprot ID P35968
Protein RefSeq NP_002244.1
mRNA RefSeq NM_002253.2

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