anti-human VEGFR-2/KDR, Agonistic monoclonal antibody Anti-Human 100 µg

In stock

Cat-Nr.
mV1001.3m-h
Size
100 µg
  €790.00

Description / anti-human VEGFR-2/KDR, Agonistic monoclonal antibody

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis. The antibody will bind near the ligand binding site of the receptor and has agonistic activity.

More Information

Size 100 µg
Source Mouse
Isotype IgG1
Biological Activity VEGFR2 activation: This antibody can induce hVEGFR2 phosphorylation in HUVECs at > 5.0 μg/mL. Western blot: Yes. Immunoprecipitation: Yes.
Clone Nr. (#8A01)
Species Reactivity Human
Formulation lyophilized
Buffer PBS
Reconstitution Centrifuge the vial prior to opening. Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human VEGFR2 N-terminal fragment (AA N30-200)).
Antigen hVEGFR2 N-terminal fragment (N30-200)
Application WB, IP, Activation of VEGFR-2
Synonyms vascular endothelial growth factor receptor-2 ; KDR; FLK1; CD309; VEGF receptor 2; kinase insert domain protein receptor
Uniprot ID P35968
Protein RefSeq NP_002244.1
mRNA RefSeq NM_002253.2

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