Description / VCAM-1
VCAM is a 110 kDa, cell surface integral membrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. The primary function of VCAM-1 is the mediation of leukocyte endothelial cell adhesion and signal transduction. VCAM-1 may play a vital role in the development of several diseases, including atherosclerosis and rheumatoid arthritis. The human VCAM-1 gene codes for a 715 amino acid transmembrane glycoprotein containing a 19 amino acid cytoplasmic domain, a 22 amino acid transmembrane domain, and a 674 amino acid extracellular domain. Recombinant Murine VCAM-1 is a 74.4 kDa glycoprotein comprising the extracellular domain (674 amino acid residues) of VCAM-1. Monomeric glycosylated VCAM-1 migrates at an apparent molecular weight of approximately 87-97 kDa by SDS-PAGE analysis under reducing conditions.
More Information
| Size | 50 µg |
|---|---|
| Source | CHO cells |
| Biological Activity | Determined by its ability to support the adhesion of human U937 cells. |
| Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 674 |
| Molecular Weight | 87-97 dDa reducing conditions |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | FKIEISPEYK TIAQIGDSMA LTCSTTGCES PLFSWRTQID SPLNAKVRTE GSKSVLTMEP VSFENEHSYL CTATCGSGKL ERSIHVDIYS FPKDPEIQFS GPLEVGKPVT VKCLAPDIYP VYRLEIDLFK GDQLMNRQEF SSEEMTKSLE TKSLEVTFTP VIEDIGKALV CRAKLHIDQI DSTLKERETV KELQVYISPR NTTISVHPST RLQEGGAVTM TCSSEGLPAP EI |
| Synonyms | Vascular Cell Adhesion Molecule 1; CD106; INCAM-100; MGC108734; MGC99561; VCAM; VCAM1; VCAM1B; VECAM1 |
| Uniprot ID | P29533 |
| Protein RefSeq | NP_035823.3 |
| mRNA RefSeq | NM_011693.3 |