Description / TNFSF11 beta
RANKL ("Receptor Activator of NF-κB Ligand") is a protein of the tumor necrosis factor (TNF) family discovered in 1997 that is significantly involved in the regulation of bone remodeling. The protein is also known as TRANCE (TNF-related activation-induced cytokine), CD254, OPGL, and ODF. RANKL is secreted by, among others, osteoblasts (cells that build bone substance) and binds to the "matching" receptor RANK of monocytic osteoclast progenitor cells, inducing their differentiation into osteoclasts (cells that degrade bone substance again). The RANK/RANKL system is a biochemical regulatory circuit that causes bone resorption to remain in healthy balance with bone formation, which is a prerequisite for the dynamic architecture of the bone system. This system can be disturbed in various diseases and is therefore of practical interest to medicine.
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More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#7F37) |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Antigen | Mouse recombinant protein TNFSF11 |
| Application | WB |
| Synonyms | Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor (ODF); Osteoprotegerin ligand (OPGL), Receptor activator of nuclear factor kappa-B ligand (RANKL), TNF-related activation-induced cytokine (TRANCE) |
| Uniprot ID | O35235 |
| Protein RefSeq | NP_035743.2 |
| mRNA RefSeq | NM_011613.3 |