Description / TMEFF1
Transmembrane Protein with EGF-like and two Follistatin-like domains 1 (TMEFF1) also known as tomoregulin-1 is a type I transmembrane glycoprotein. TMEFF1 contains two follistatin modules and an EGF domain in its extracellular domain, a transmembrane domain and a short cytoplasmic tail. The extracellular domain of TMEFF1 can be released as a soluble protein. TMEFF1 is predominantly expressed in brain, but is downregulated in brain neoplasms. TMEFF1 selectively regulates nodal but not activin signaling through direct binding to the nodal co-receptor, Cripto.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#7S12) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with extracellular domain of Human Transmembrane protein wth EGF-like and two Follistatin-like domains (TMEFF1), also called Tomoregulin-1. |
| Antigen | EC domain of human TMEFF1 (also called Tomoregulin-1) |
| Application | WB |
| Synonyms | TMEFF1; TR-1; H7365; C9orf2; CT120.1 |
| Uniprot ID | Q8IYR6 |
| Protein RefSeq | NP_003683.2 |
| mRNA RefSeq | NM_003692.4 |