anti-mouse TIMP-1 monoclonal antibody Anti-Mouse 100 µg

In stock

Cat-Nr.
103-M277
Size
100 µg
  €533.00

Description / anti-mouse TIMP-1 monoclonal antibody

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

More Information

Size 100 µg
Source Rat
Isotype IgG2
Clone Nr. (#6A34)
Species Reactivity Mouse
Formulation lyophilized
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant TIMP-1. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Antigen mouse recombinant TIMP-1 protein
Application WB
Synonyms Timp1; Clgi; Timp; TIMP-1
Uniprot ID P12032
Protein RefSeq NP_035723.2
mRNA RefSeq NM_011593.2

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