Description / TIE-1
TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.
More Information
| Size | 200 µg |
|---|---|
| Source | Rabbit |
| Biological Activity | Western Blot: use at 2-5 µg/ml. |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% |
| Antigen | Recombinant mouse sTIE-1 (RT Cat# S01-M42) |
| Application | WB |
| Synonyms | Tie1; TIE; tie-1; D430008P04Rik |
| Uniprot ID | Q06806 |
| Protein RefSeq | NP_035717.2 |
| mRNA RefSeq | NM_011587.2 |