Description / TGFR-1 (ALK-1)
ALKs 1-7 are type I serine/threonine kinase receptors for TGF-beta superfamily members. They undergo hetero-oligomerization with type II serine/threonine kinase receptors to transduce signals, usually through Smad proteins. Alk-1 binds TGF-beta and Alk-7 is thought to bind nodal.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Biological Activity | WB: 1:200-800; IHC (Paraffin): 1:50 |
| Clone Nr. | (#8G33) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human extracellular domain of ALK1. The IgG2 fraction of the culture supernatant was purified by Protein G affinity chromatography. |
| Antigen | human TGF RI (ALK1) EC domain |
| Application | WB, IHC |
| Synonyms | HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; ACVRL1; activin A receptor type II-like 1 |
| Uniprot ID | P37023 |
| Protein RefSeq | NP_000011.2 |
| mRNA RefSeq | NM_000020.2 |