human TGF-beta 3 (Animal Free) protein Human 10 µg

In stock

Cat-Nr.
100-107-AF
Size
10 µg
  €272.00

Description / human TGF-beta 3 (Animal Free) protein

The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

More Information

Size 10 µg
Source E. coli
Biological Activity Determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of 2 x 107 units/mg.
Purity Confirmation ≥ 98% by SDS-PAGE gel and HPLC analyses.
Length [aa] 112
Molecular Weight 25 kDa
Species Reactivity Human, Mouse, Rat, Salamander
Formulation lyophilized
Protein Sequence ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
Synonyms TGFB3; ARVD; TGF-beta3
Uniprot ID P10600
Protein RefSeq NP_003230
mRNA RefSeq NM_003239

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SKU: 102-P50
€271.00

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