human TGF-alpha (Animal Free) protein Human 20 µg
Description / human TGF-alpha (Animal Free) protein
TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces anchorage-independent transformation in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant Human TGF-α is a 50 amino acid polypeptide (5.5 kDa), which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
More Information
Size | 20 µg |
---|---|
Source | E. coli |
Biological Activity | Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. |
Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
Length [aa] | 50 |
Molecular Weight | 5.5 kDa |
Species Reactivity | Chicken, Horse, Human, Mouse, Rat |
Formulation | lyophilized |
Protein Sequence | VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA |
Synonyms | TGFA; TFGA |
Uniprot ID | P01135 |
Protein RefSeq | NP_003227.1 |
mRNA RefSeq | NM_003236 |