Sonic Hedgehog (N-terminal)

In stock

Cat-Nr.
101-M833
Size
100 µg
  €533.00

Description / Sonic Hedgehog (N-terminal)

Members of the Hedgehog (Hh) family are highly conserved proteins which are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh) are structurally related and share a high degree of amino-acid sequence identity (e.g., Shh and Ihh are 93% identical). The biologically active form of Hh molecules is obtained by autocatalytic cleavage of their precursor proteins and corresponds to approximately the N-terminal one half of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can substitute for each other in experimental systems. Recombinant E. coli derived Human Sonic HedgeHog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the natural occurring chemically modified Cys residue.

More Information

Size 100 µg
Source Rat
Isotype IgG2
Clone Nr. (#2G19)
Species Reactivity Human
Formulation lyophilized
Buffer PBS
Reconstitution Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Antigen Recombinant Human Sonic Hedgehog
Application WB
Synonyms Sonic Hedgehog
Uniprot ID Q15465
Protein RefSeq NP_000184.1
mRNA RefSeq NM_000193.2

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