Mouse FGF-21
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| Cat-Nr. | M10-047 |
| Size | 25 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Length [aa] | 182 |
| Molecular Weight | 20.1 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. |
| Species Reactivity | Mouse |
| Synonyms | Fibroblast Growth Factor-21, FGFL |
| Description | FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through the FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Murine FGF-21 is a 20.1 kDa protein containing 182 amino acid residues. |
| Protein Sequence | MAYPIPDSSP LLQFGGQVRQ RYLYTDDDQD TEAHLEIRED GTVVGAAHRS PESLLELKAL KPGVIQILGV KASRFLCQQP DGALYGSPHF DPEACSFREL LLEDGYNVYQ SEAHGLPLRL PQKDSPNQDA TSWGPVRFLP MPGLLHEPQD QAGFLPPEPP DVGSSDPLSM VEPLQGRSPS YAS |
| Uniprot ID | Q9JJN1 |
| Protein RefSeq | NP_064397.1 |
| mRNA RefSeq | NM_020013.4 |
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