Human FGF-8a
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| Cat-Nr. | 100-438 |
| Size | 25 µg |
| Price | 199 € |
| Source | CHO cells |
| Formulation | lyophilized |
| Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
| Length [aa] | 182 |
| Molecular Weight | 21.2 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by a cell proliferation assay using balb/c 3T3 cells. |
| Species Reactivity | Human |
| Synonyms | Fibroblast Growth Factor-8, FGF-8a, AIGF, HBGF-8 |
| Description | FGF-8 is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8a, FGF-8b, FGF-8e and FGF-8f. The human and murine FGF-8a and FGF-8b are identical, unlike human and mouse FGF-8e and FGF-8f, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. CHO cell-derived recombinant human FGF-8a is a 21.2 kDa protein consisting of 182 amino acid residues. |
| Protein Sequence | QHVREQSLVT DQLSRRLIRT YQLYSRTSGK HVQVLANKRI NAMAEDGDPF AKLIVETDTF GSRVRVRGAE TGLYICMNKK GKLIAKSNGK GKDCVFTEIV LENNYTALQN AKYEGWYMAF TRKGRPRKGS KTRQHQREVH FMKRLPRGHH TTEQSLRFEF LNYPPFTRSL RGSQRTWAPE PR |
| Uniprot ID | P55075-2 |
| Protein RefSeq | NP_149355.1 |
| mRNA RefSeq | NM_033165.3 |
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