Human TL-1A (Animal Free)
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| Cat-Nr. | 100-294-AF |
| Size | 20 µg |
| Price | 230 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 194 |
| Molecular Weight | 22 kDa |
| Endotoxin Levels | < 0.01 ng/ug of protein (< 0.1 EU/ug) |
| Biological Activity | Determined by its ability to stimulate IFN-γ production by human PBMC co-stimulated with Human IL-12 and Human IL-18. |
| Species Reactivity | Human |
| Synonyms | TNFSF15; TL1; TL1A; VEGI; VEGI192A |
| Description | TL‐1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in the placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL‐1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NF‐κB activation, caspase activity, and apoptosis in responding cell lines. TL‐1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant Human TL‐1A is a 22.1 kDa polypeptide of 195 amino acid residues. |
| Protein Sequence | QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL |
| Uniprot ID | O95150 |
| Protein RefSeq | NP_005109 |
| mRNA RefSeq | NM_005118 |
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