Human BD-1 (36aa)
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| Cat-Nr. | 100-132S |
| Size | 5 µg |
| Price | 95 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 36 |
| Molecular Weight | 3.9 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100-1000 ng/ml. |
| Species Reactivity | Bacteria, Human |
| Synonyms | DEFB1; BD1; HBD1; DEFB-1; DEFB101 |
| Description | Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-1 is a 3.9 kDa protein containing 36 amino acid residues. |
| Protein Sequence | DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK |
| Uniprot ID | P60022 |
| Protein RefSeq | NP_5209.1 |
| mRNA RefSeq | NM_005218 |
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