Human NT-3 (Animal Free)
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| Cat-Nr. | 100-086S-AF |
| Size | 2 µg |
| Price | 135 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 120 |
| Molecular Weight | 13.6 kDa |
| Endotoxin Levels | < 0.01 ng/ug of protein (< 0.1 EU/ug) |
| Biological Activity | Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. |
| Species Reactivity | Human, Mouse, Rat |
| Synonyms | NTF3; NT3; HDNF; NGF2; NGF-2 |
| Description | NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues). |
| Protein Sequence | MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT |
| Uniprot ID | P20783 |
| Protein RefSeq | NP_001096124.1 |
| mRNA RefSeq | NM_001102654 |
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