Rat Anti-Mouse Siglec-E
Slide this table
| Cat-Nr. | 103-M69 |
| Size | 100 µg |
| Price | 380 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#17E34) |
| Isotype | IgG2 |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Antigen | Mouse Siglec-E |
| Application | FC |
| Synonyms | Sialic acid-binding Ig-like lectin 12, Siglec-12, Myeloid inhibitory siglec, MIS, Sialic acid-binding Ig-like lectin 5, Siglec-5, Sialic acid-binding Ig-like lectin E, Siglec-E, Sialic acid-binding Ig-like lectin-like 1, Siglec-L1, Siglece, Siglecl1 |
| Description | Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: siglecs-1, -2, and -4, and a siglec-3/CD33-related subgroup (siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens. |
| Uniprot ID | Q91Y57 |
| Protein RefSeq | NP_112458.2. |
| mRNA RefSeq | NM_031181.2 |
All prices plus VAT + possible delivery charges