Rat Anti-Mouse CXCR4
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| Cat-Nr. | 103-M522 |
| Size | 100 µg |
| Price | 380 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#30L4) |
| Isotype | IgG2 |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Antigen | Mouse recombinant CXCR4 |
| Application | FC, IHC |
| Synonyms | C-X-C chemokine receptor type 4, CXC-R4; CXCR-4, Fusin, Leukocyte-derived seven transmembrane domain receptor (LESTR), Pre-B-cell-derived chemokine receptor (PB-CKR), Stromal cell-derived factor 1 receptor (SDF-1 receptor) |
| Description | CXCR4 (short for CXC motif chemokine receptor 4) is a receptor protein of the chemokine receptor family. CXCR4 is common in many cells of the hematopoietic system and is expressed in particular by many stem cells and tumor cells. This receptor is activated by the chemokine CXCL12 and the cytokine macrophage migration inhibitory factor (MIF). CXCR4 plays a key role in the mobilization and targeted migration of stem cells to their storage (e.g., fetal liver, bone marrow) or their sites of use in organ formation (organogenesis) and organ and wound healing. Pathophysiologically, CXCR4 is involved in tumor growth and metastatic spread as well as inflammatory processes. In addition, CXCR4 is the primary co-receptor for T cell-using (T-tropic) HI viruses. |
| Uniprot ID | P70658 |
| Protein RefSeq | NP_034041.2 |
| mRNA RefSeq | NM_009911.3 |
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