Rat Anti-Mouse Cathepsin L
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| Cat-Nr. | 103-M319 |
| Size | 100 µg |
| Price | 380 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#5G14) |
| Isotype | IgG2 |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Cathepsin-L. |
| Antigen | recombinant mouse Cathepsin-L |
| Application | WB, IHC |
| Synonyms | Ctsl; fs; MEP; nkt; Ctsl1; 1190035F06Rik |
| Description | Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinasetype plasminogen activator, which is activated by Cathepsin L cleavage. Cathepsin L has also been shown to proteolytically inactivate α1antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract. These observations, combined with the demonstration of increased Cathepsin L activity in the epithelial lining fluid of the lungs of emphysema patients, have led to the suggestion that the enzyme may be involved in the progression of this disease. Cathepsin L has also been identified as a major excreted protein of transformed fibroblasts, indicating the enzyme could be involved in malignant tumor growth. In Cathepsin L deficient mice, it appears to play a critical role in cardiac morphology and function, epidermal homeostasis, regulation of the hair cycle, and MHC class I-mediated antigen presentation in cortical epithelial cells of the thymus. Mouse Cathepsin L is synthesized as a 334 amino acid precursor with a signal peptide (residues 117), a pro region (residues 18-113), and a mature chain (residues 114-334). |
| Uniprot ID | P06797 |
| Protein RefSeq | NP_034114 |
| mRNA RefSeq | NM_009984 |
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