Mouse Anti-Human TIE-1
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| Cat-Nr. | 101-M46 |
| Size | 100 µg |
| Price | 255 € |
| Category | Monoclonal Antibody |
| Clone Nr. | (#8C9) |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots. |
| Preparation | The monoclonal antibody was produced with the help of BALB/c mice using recombinant human soluble extracellular TIE-1 as the immunizing antigen. Mouse IgG1 antibody (#8C9) from hybridomas was purified from cell culture supernatant by Protein G chromatography. |
| Antigen | recombinant human soluble TIE-1 |
| Application | ELISA, WB |
| Synonyms | TIE1; TIE; JTK14 |
| Description | TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. |
| Uniprot ID | P35590 |
| Protein RefSeq | NP_005415 |
| mRNA RefSeq | NM_005424 |
Figures
Western analysis of recombinant human and mouse soluble TIE receptors using a monoclonal antibody directed against human recombinant soluble TIE-1. There is no cross reactivity with mouse sTIE-1 and human and mouse sTIE-2 visible.
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