Mouse Anti-Human IFN gamma
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Cat-Nr. | 101-M169 |
Size | 500 µg |
Price | 275 € |
Category | Monoclonal Antibody |
Isotype | IgG1, kappa |
Species Reactivity | Human |
Formulation | lyophilized from PBS |
Buffer | PBS |
Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
Preparation | Produced in BALB/c mice using highly pure (>98%) recombinant human IFN-gamma as the immunizing antigen. This IgG1K antibody was purified from ascites fluid by antigen affinity chromatography. |
Antigen | Recombinant human IFN-gamma |
Application | ELISA, WB |
Synonyms | IFNG; IFG; IFI |
Description | IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.7 kDa protein containing 143 amino acid residues. |
Uniprot ID | P01579 |
Protein RefSeq | NP_000610.2 |
mRNA RefSeq | NM_000619 |
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