Description / Presenilin-1
Presenilin1 (PS1) is a 467 amino acid multipass lysosomal membrane protein that is a component of the gamma secretase complex. It is cleaved by endoproteolysis at or near amino acid 298 to generate N- and C- terminal fragments. Some mutations in PS 1 are associated with the risk of early onset familial Alzheimer's disease.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#7G6) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human Presenilin-1. |
| Antigen | recombinant human Presenilin-1 |
| Application | WB, IHC (P) |
| Synonyms | PSEN1; AD3; FAD; PS1; PS-1; S182 |
| Uniprot ID | P49768 |
| Protein RefSeq | NP_015557.2 |
| mRNA RefSeq | NM_007318.2 |