Description / NKp46
NKp30/NCR3, NKp44/NCR2, and NKp46/NCR1 are termed natural cytotoxicity receptors (NCR). These receptors are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp44 is induced upon activation of resting NK cells with IL-2 and can bind to viral hemagglutinins. NK-mediated dendritic cell (DC) recognition is highly dependent on engagement of NKp30 and may result in lysis of the DC.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#8F24) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with extracellular domain of human recombinant protein of NKp46, also called NCR1 (natural cytotoxicity triggering receptor 1). |
| Antigen | recombinant human NKp46 |
| Application | WB, IHC (F), FC |
| Synonyms | NCR1; LY94; CD335; NKP46; NK-p46 |
| Uniprot ID | O76036 |
| Protein RefSeq | NP_004820.1 |
| mRNA RefSeq | NM_004829.6 |