anti-human MMP-14 monoclonal antibody Anti-Human 100 µg
Description / anti-human MMP-14 monoclonal antibody
As the first member of membrane type (MT) MMPs, MMP-14, also known as MT1MMP, plays an important role in extracellular matrix (ECM) remodeling by being able to degrade type I collagen, activate pro MMP2 and process cell adhesion molecules such as CD44 and integrin αV. MMP-14 is therefore a key enzyme in many physiological and pathological processes such as angiogenesis and tumor invasion. Structurally, MMP14 consists of the following domains: a pro domain containing the furin cleavage site, a catalytic domain containing the zinc binding site, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplamasic tail. Recombinant Human MMP-14 consists of the pro and catalytic domains, which can be activated by treatment with furin.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#9E57) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant human MMP-14). |
| Antigen | recombinant human MMP-14 |
| Application | WB, IHC (P), FC, Detection Ab |
| Synonyms | MMP14; 1; MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; MT1-MMP; MT-MMP 1 |
| Uniprot ID | P50281 |
| Protein RefSeq | NP_004986.1 |
| mRNA RefSeq | NM_004995.2 |