Description / anti-human MCP-4 monoclonal antibody
Monocyte Chemoattractant Protein-4 (MCP-4), is a CC chemokine that acts as a chemoattractant for monocytes, eosinophils and T cells and as an activator of basophils. Human MCP-4/CCL13 cDNA encodes a 98 amino acid residue precursor protein with a 23 amino acid residue hydrophobic signal peptide that is cleaved to yield an 8 kDa, 75 aa mature CCL13. Mature MCP-4 lacks any potential N-glycosylation sites and shares a pyroglutamate proline motif with other human MCP proteins. Human MCP-4 is most homologous to MCP-1, -3 and Eotaxin, exhibiting approximately 65-66% amino acid sequence identity. CCL13 or MCP-4 mRNA is expressed by a number of activated cell types, including endothelial cells, macrophages, bronchial epithelium and type II alveolar cells, and perhaps lymphocytes. The bioactivities of MCP-4 are mediated by the CC chemokine receptors CCR2 and CCR3.
More Information
| Size | 500 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1, kappa |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced in BALB/c mice using recombinant human MCP-4 as the immunizing antigen. This IgG1, antibody was purified from a Protein A chromatography column. |
| Antigen | Recombinant Human MCP-4 |
| Application | ELISA, WB, N |
| Synonyms | CCL13; NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13 |
| Uniprot ID | Q99616 |
| Protein RefSeq | NP_005399 |
| mRNA RefSeq | NM_005408 |