Description / human Maspin (SerpinB5) protein
Maspin (mammary serine protease inhibitor) is a non-inhibitory serpin that is expressed predominantly in normal mammary epithelial cells but at significantly reduced levels or absent in most breast carcinomas. It has the ability to block the growth, invasiveness, and metastatic potential of breast and lung tumors. This anti-tumor activity is achieved, in part, by the ability of Maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells. Recombinant human Maspin is a 42.2 kDa non-glycosylated protein containing 375 amino acid residues.
More Information
Size | 5 µg |
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Source | E. coli |
Biological Activity | Data not available. |
Purity Confirmation | > 97% by SDS-PAGE & HPLC analyses |
Length [aa] | 375 |
Molecular Weight | 42.1 kDa |
Species Reactivity | Human |
Formulation | lyophilized |
Protein Sequence | MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KECPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LL |
Synonyms | SERPINB5; PI5; maspin |
Uniprot ID | P36952 |
Protein RefSeq | NP_002630.2 |
mRNA RefSeq | NM_002639 |