Description / M-CSF
Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Macrophage Colony Stimulating Factor Human Recombinant produced in E. coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 36.8 KD. M-CSF is purified by proprietary chromatographic techniques.
More Information
| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The biological activity was determined by the dose-dependent induction of proliferation in NFS60 cells (Murine myeloid Leukemia cell line). |
| N Terminal Sequence | MEEVS |
| Purity Confirmation | > 95% by SDS-PAGE |
| Length [aa] | 159 |
| Molecular Weight | 36.8 kDa |
| Species Reactivity | Monkey, Mouse, Rat, Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Protein Sequence | MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS |
| Synonyms | CSF1; MCSF; CSF-1 |
| Uniprot ID | P09603 |
| Protein RefSeq | NP_000748.3 |
| mRNA RefSeq | NM_000757 |