Description / Lymphotoxin
Lymphotoxin-alpha (LT alpha) and Lymphotoxin-beta (LT beta) are members of the TNF superfamily designated TNFSF1 and TNFSF3, respectively. LT alpha is a soluble protein while LT beta is a type II transmembrane protein. Secreted LT alpha will assemble as a homotrimer, LT alpha 3, or as a complex with membrane-associated LT beta to generate two types of heterotrimers, LT alpha 1/beta 2 and LT alpha 2/beta 1. Lymphotoxins are expressed by activated CD4+ T cells, unpolarized IL-2-secreting effector T cells, and Th1 effector cells.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#12B4) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Lymphotoxin α/β. |
| Antigen | recombinant human Lymphotoxin alpha/beta |
| Application | N |
| Synonyms | LTA; LT; TNFB; TNFSF1 |
| Uniprot ID | P01374 |
| Protein RefSeq | NP_001153212.1 |
| mRNA RefSeq | NM_001159740.1 |