Description / Kremen-1
Kremen (Kringle-containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Two related members, Kremen-1 and -2, have been identified. Kremens bind a subset of the secreted Dickkopf (Dkk) proteins with high affinity. The canonical Wnt signaling pathway receptor complex composed of Wnt, the seven-transmembrane domain receptor Frizzled, and the receptor-related protein 5/6 (LRP5/6) coreceptor, is modulated by Kremens and Dkk proteins.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#6K45) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of Kremen-1 extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affi |
| Antigen | Mouse recombinant EC domain of Kremen-1 |
| Application | WB |
| Synonyms | Kremen1; Krm1; Kremen; AV002070 |
| Uniprot ID | Q99N43 |
| Protein RefSeq | NP_115772.2 |
| mRNA RefSeq | NM_032396.3 |