Description / Interferon alpha/beta R2
IFN-alpha/beta R2, also known as IFNAR2, is a 100 kDa component of the class II cytokine receptor that binds the type I interferons IFN-alpha, IFN-beta, and IFN-omega. IFN-alpha/beta R2 associates with the 125 kDa IFN-alpha/beta R1 component to form a receptor complex that transmits antiviral and antiproliferative signals. Down-regulation of the receptor is accomplished by ubiquitination and degradation. A soluble form of the protein, corresponding to the extracellular ligand-binding domain, is generated by alternative splicing.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG2 |
| Clone Nr. | (#5L16) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of INFa/b R2 extracellular domain |
| Antigen | recombinant mouse protein of INF alpha/beta R2 |
| Application | WB, IHC |
| Synonyms | Ifnar2; Ifnar-2; AI74730 ; Interferon receptor |
| Uniprot ID | P48551 |
| Protein RefSeq | NP_000865.2 |
| mRNA RefSeq | NM_000874.3 |