Description / Insulin R
The insulin receptor is a type I transmembrane receptor tyrosine kinase. Ligand binding results in receptor autophosphorylation, and subsequent downstream signaling important in metabolic regulation, cell growth, differentiation, and apoptosis. Mutations in the insulin receptor gene have been linked to insulin-resistant diabetes mellitus and noninsulin-dependent diabetes mellitus.
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| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2 |
| Clone Nr. | (#2A12) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Insulin R (also called CD220) extracellular domain. |
| Antigen | Human recombinant Insulin R EC domain |
| Application | WB |
| Synonyms | INSR; HHF5; CD220 |
| Uniprot ID | P06213 |
| Protein RefSeq | NP_000199.2 |
| mRNA RefSeq | NM_000208.2 |