rat IL-6 protein Rat 2 µg

In stock

Cat-Nr.
R20-008S
Size
2 µg
  €112.00

Description / rat IL-6 protein

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant rat IL-6 is a 21.7 kDa protein containing 187 amino acid residues.

More Information

Size 2 µg
Source E. coli
Biological Activity The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < 0.01 ng/ml, corresponding to a specific activity of > 1 x 108 units/mg.
Purity Confirmation > 98% by SDS-PAGE & HPLC analyses
Length [aa] 187
Molecular Weight 21.7 kDa
Species Reactivity Mouse, Bacteria, Rat, Human
Formulation lyophilized
Protein Sequence MFPTSQVRRG DFTEDTTHNR PVYTTSQVGG LITYVLREIL EMRKELCNGN SDCMNSDDAL SENNLKLPEI QRNDGCFQTG YNQEICLLKI CSGLLEFRFY LEFVKNNLQD NKKDKARVIQ SNTETLVHIF KQEIKDSYKI VLPTPTSNAL LMEKLESQKE WLRTKTIQLI LKALEEFLKV TMRSTRQT
Synonyms Il6; ILg6; Ifnb2
Uniprot ID P20607
Protein RefSeq NP_036721
mRNA RefSeq NM_012589

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