Description / IL-6
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
More Information
| Size | 20 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The ED50 as determined by the dose-dependent stimulation of murine hybridoma B9 cells is in the range of 5-20 pg/ml. |
| N Terminal Sequence | MFPTS |
| Purity Confirmation | > 98% by SDS-PAGE & Coomassie stain |
| Length [aa] | 188 |
| Molecular Weight | 21.7 kDa |
| Species Reactivity | Monkey, Mouse, Rat, Trout |
| Formulation | lyophilized |
| Buffer | 50 mM Acetic Acid |
| Protein Sequence | MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT |
| Synonyms | Il6; Il-6 |
| Uniprot ID | P08505 |
| Protein RefSeq | NP_112445.1 |
| mRNA RefSeq | NM_031168 |