Description / IL-4 receptor alpha, soluble
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc). The type I receptor contains, in addition to the γc, an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE.Â
More Information
Size | 100 µg |
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Source | Rabbit |
Isotype | Rabbit IgG |
Clone Nr. | Rabbit IgG |
Species Reactivity | Human |
Formulation | lyophilized |
Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
Preparation | Anti-Human sIL-4 Receptor α-specific antibody was purified by affinity chromatography employing an immobilized-Human sIL-4 Receptor α matrix. |
Antigen | CHO cells derived Recombinant Human IL-4 Receptor α |
Application | WB, ELISA |
Synonyms | soluble Interleukin-4Rα, soluble IL-4 Receptor alpha, CD124 |
Uniprot ID | P24394 |
Protein RefSeq | NP_000409.1 |
mRNA RefSeq | NM_000418 |