Description / rat IL-4 protein
Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
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| Size | 5 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Tested by its ability to suppress LPS-induced TNF-α and MIP-2 production in mouse splenocytes. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 126 |
| Molecular Weight | 14 kDa |
| Species Reactivity | Mouse, Rat, Human |
| Formulation | lyophilized |
| Protein Sequence | MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS |
| Synonyms | Il4; Il4e12 |
| Uniprot ID | P20096 |
| Protein RefSeq | NP_958427 |
| mRNA RefSeq | NM_201270 |