Description / IL-3 receptor beta
The high-affinity receptors for Interleukin-3 (IL-3), IL-5, and Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) consist of a cytokine-specific a chain, and a shared common beta chain subunit (CD131) that is essential for receptor signaling. CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective heteroreceptor complex. Phosphorylation of CD131 following receptor activation imparts growth and survival signals to the responding hematopoietic cells.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG1 |
| Clone Nr. | (#42A7) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of IL-3R extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affini |
| Antigen | recombinant mouse protein of IL-3R beta extracellular domain |
| Application | WB |
| Synonyms | Csf2rb2; Bil3; Il3r; AIC2A; Il3rb; Il3rb2; BetaIl3; Csfgmrb |
| Uniprot ID | P26954 |
| Protein RefSeq | NP_031807.1 |
| mRNA RefSeq | NM_007781.2 |