Description / mouse IL-3 protein
IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.
More Information
| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is in the range of 20-100 pg/ml. |
| N Terminal Sequence | ASISGR |
| Purity Confirmation | > 98% by SDS-PAGE & Coomassie stain |
| Length [aa] | 140 |
| Molecular Weight | 15.8 kDa |
| Species Reactivity | Rat, Mouse, Human, Monkey, Bacteria, Gerbil |
| Formulation | lyophilized |
| Buffer | PBS |
| Protein Sequence | ASISGRDTHR LTRTLNCSSI VKEIIGKLPE PELKTDDEGP SLRNKSFRRV NLSKFVESQG EVDPEDRYVI KSNLQKLNCC LPTSANDSAL PGVFIRDLDD FRKKLRFYMV HLNDLETVLT SRPPQPASGS VSPNRGTVEC |
| Synonyms | Il3; BPA; PSF; HCGF; Il-3; MCGF; Csfmu |
| Uniprot ID | P01586 |
| Protein RefSeq | NP_034686.2 |
| mRNA RefSeq | NM_010556.4 |