Description / IL-23
IL-23 is a proinflammatory heterodimeric protein composed of two subunits, a unique p19 subunit and a p40 subunit, which is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17 mediated responses. Recombinant IL-23 is a 53.5 kDa heterodimeric protein consisting of two subunits, p19 (170 amino acids) and p40 (306 amino acids).
More Information
| Size | 2 µg |
|---|---|
| Source | Insect cells |
| Biological Activity | Determined by its ability to stimulate the proliferation of HEK-BlueTM-IL-23 reporter cells. |
| Purity Confirmation | > 95% by SDS-PAGE & HPLC analyses |
| Length [aa] | 476 |
| Molecular Weight | 53.5 kDa |
| Species Reactivity | Mouse, Human |
| Formulation | lyophilized |
| Protein Sequence | p19 Subunit: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWT |
| Synonyms | IL-23 |
| Uniprot ID | Q9NPF7 |
| Protein RefSeq | NP_057668.1 |
| mRNA RefSeq | NM_016584.2 |