Description / mouse IL-22 protein
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 32-34 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.
More Information
| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Assay#1: Determined by its ability to activate STAT following receptor ligand interaction. Assay#2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED50 for this effect is 1.0-2.0 ng/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 146 |
| Molecular Weight | 33.4 kDa |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Protein Sequence | MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV |
| Synonyms | IL22; IL-22; Iltif; IL-22a; ILTIFa |
| Uniprot ID | Q9JJY9 |
| Protein RefSeq | NP_058667.1 |
| mRNA RefSeq | NM_016971 |