Description / IL-22 BP
Interleukin 22 binding protein (IL-22BP), also known as cytokine receptor family (CRF) 2-10, CRF2-X, and IL-22 RA2, is a secreted glycoprotein belonging to the type II cytokine receptor family. IL-22BP antagonizes IL-22 activity by specifically binding IL-22 with high affinity and blocking its interaction with the cell surface IL-22 receptor heteromeric complex composed of IL-22R and IL-10R2 (IL-10 R beta). The highest levels of IL-22BP expression are found in breast, lungs and colon.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Biological Activity | Western blotting: 1:500- 1:2000 |
| Clone Nr. | (#6G47) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-22BP. |
| Antigen | recombinant human IL-22BP |
| Application | WB |
| Synonyms | IL22RA2; CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2 |
| Uniprot ID | Q969J5 |
| Protein RefSeq | NP_443194.1 |
| mRNA RefSeq | NM_052962.2 |