anti-mouse IL-20 receptor alpha monoclonal antibody Anti-Mouse 100 µg

In stock

Cat-Nr.
103-M249
Size
100 µg
  €533.00

Description / anti-mouse IL-20 receptor alpha monoclonal antibody

IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.

More Information

Size 100 µg
Source Rat
Isotype IgG1
Clone Nr. (#11C42)
Species Reactivity Mouse
Formulation lyophilized
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of IL-20 Rα extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affi
Antigen Mouse recombinant EC domain of IL-20 R alpha
Application WB
Synonyms Il20ra, E230031K19
Uniprot ID Q6PHB0
Protein RefSeq NP_766374.1
mRNA RefSeq NM_172786.2

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