anti-human IL-20 receptor alpha monoclonal antibody Anti-Human 100 µg

In stock

Cat-Nr.
101-M504
Size
100 µg
  €533.00

Description / anti-human IL-20 receptor alpha monoclonal antibody

IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.

More Information

Size 100 µg
Source Mouse
Isotype IgG1
Clone Nr. (#9F40)
Species Reactivity Human
Formulation lyophilized
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-20 Ra extracellular domain.
Antigen recombinant human IL-20 Ralpha EC domain
Application WB, IHC (P)
Synonyms IL20RA; IL-20R1; ZCYTOR7
Uniprot ID Q9UHF4
Protein RefSeq NP_055247.3
mRNA RefSeq NM_014432.2

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