IL-2 receptor alpha Anti-Human 100 µg

In stock

Cat-Nr.
102-P47
Size
100 µg
  €271.00

Description / IL-2 receptor alpha

The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2R alpha, IL-2R beta, and IL-2R gamma. The IL-2R alpha is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2R alpha releases the entire extracellular domain of IL-2R alpha thereby generating a 219 amino acid soluble protein called soluble IL-2R alpha (sIL-2R alpha). The homodimeric form binds IL-2 (KD=10mM) and facilitates IL-2 signaling. The secreted sIL-2R alpha is expressed on leukemia cells, lymphoma cells, newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant human sIL-2R alpha is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2R alpha. Due to glycosylation, IL-2R alpha has an approximate molecular weight of 31 kDa based on SDS-PAGE gel and Mass Spectrometry.

More Information

Size 100 µg
Source Rabbit
Clone Nr. Rabbit IgG
Species Reactivity Human
Formulation lyophilized from PBS
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and Storage The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Preparation Produced from sera of rabbits immunized with highly pure recombinant human sIL-2 Receptor alpha. Anti-Human sIL-2 Receptor alpha-specific antibody was purified by affinity chromatography employing immobilized human sIL-2 Receptor alpha as matrix.
Antigen Recombinant Human sIL-2 Receptor α (CHO cell derived)
Application ELISA, WB
Synonyms soluble IL-2 receptor, TAC-antigen, CD25 antigen, IL2RA; CD25; IL2R; TCGFR; IDDM10
Uniprot ID P01589
Protein RefSeq NP_000408.1
mRNA RefSeq NM_000417.2

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