rat IL-13 (113aa) protein Rat 10 µg

In stock

Cat-Nr.
R20-049
Size
10 µg
  €221.00

Description / rat IL-13 (113aa) protein

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 12.3 kDa protein consisting of 113 amino acid residues.

More Information

Size 10 µg
Source E. coli
Biological Activity The ED50 was determined by the dose-dependent proliferation of TF-1 cells is < 5.0 ng/ml, corresponding to a specific activity of > 2 x 105 units/mg.
Purity Confirmation > 98% by SDS-PAGE & HPLC analyses
Length [aa] 113
Molecular Weight 12.3 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence TPGPVRRSTS PPVALRELIE ELSNITQDQK TSLCNSSMVW SVDLTAGGFC AALESLTNIS SCNAIHRTQR ILNGLCNQKA SDVASSPPDT KIEVAQFISK LLNYSKQLFR YGH
Synonyms il13
Uniprot ID P42203
Protein RefSeq NP_446280.1
mRNA RefSeq NM_053828

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