human IGF-BP3 (Animal Free) protein Human 5 µg

In stock

Cat-Nr.
100-199S-AF
Size
5 µg
  €139.00

Description / human IGF-BP3 (Animal Free) protein

IGF-BP3 is a 30 kDa, cysteine-rich secreted protein.  It is the major IGF binding protein present in the plasma of human and animals, and it is also found in α-granules of platelets.  In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity.  Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly.  The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors, such as Bombesin, Vasopressin, PDGF, and EGF.  Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.

More Information

Size 5 µg
Source E. coli
Biological Activity Determined by its ability to inhibit IGF-II induced proliferation of MCF-7.  The expected ED50 is ≤ 0.2 μg/ml in the presence of 15 ng/ml of human IGF-II.
Purity Confirmation ≥ 98% by SDS-PAGE gel and HPLC analyses.
Length [aa] 264
Molecular Weight 28.8 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KR
Synonyms IGFBP3; IBP3; BP-53
Uniprot ID P17936
Protein RefSeq NP_001013416
mRNA RefSeq NM_001013398

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