Description / IFN lambda2
Human/mouse IFN-lambda 2 or IL-28A, IL-28B (or IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.
More Information
Size | 100 µg |
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Source | Rabbit |
Clone Nr. | Rabbit IgG |
Species Reactivity | Human |
Formulation | lyophilized from PBS |
Buffer | PBS |
Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
Preparation | Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIFN-λ2. Anti-Human IFN-λ2 specific antibody was purified by affinity chromatography employing immobilized hIFN-λ2 matrix. |
Antigen | Recombinant human IFN-lambda2 |
Application | ELISA, WB |
Synonyms | IL29; IFNL1; IL-29 |
Uniprot ID | Q8IZJ0 |
Protein RefSeq | NP_742150.1 |
mRNA RefSeq | NM_172138 |