human IFN beta protein Human 20 µg

In stock

Cat-Nr.
100-191
Size
20 µg
  €221.00

Description / human IFN beta protein

Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-alpha is an acid stable molecule that signals through IFN-alpha/betaR, which is also used by IFN-beta. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-alpha contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant human IFN-beta is a 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFN-beta has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.

More Information

Size 20 µg
Source CHO cells
Biological Activity Assay #1: Determined by its ability to induce STAT1/STAT2 activation in human COLO 205 ISRE LUC reporter cells. Assay #2: Determined by a cytotoxicity assay using human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml (specific activity of ≥ 1 x 10^7 units/mg
Purity Confirmation > 95% by SDS-PAGE & HPLC analyses
Length [aa] 166
Molecular Weight 20 kDa
Species Reactivity Monkey, Mouse, Human
Formulation lyophilized
Protein Sequence MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
Synonyms IFNB1; IFB; IFF; IFNB
Uniprot ID P01574
Protein RefSeq NP_002167.1
mRNA RefSeq NM_002176

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