Description / IFN alpha/beta Receptor 1
IFN-alpha/beta R1, also known as IFNAR1, is a 120 kDa component of the class II cytokine receptor that contributes to the functional receptor for type I IFNs. IFN-alpha/beta R1 associates with the 100 kDa IFN-alpha/beta R2 component to form a receptor complex that transmits anti-viral and anti-proliferative signals. Down-regulation of the receptor is accomplished by ubiquitination and degradation.
More Information
| Size | 100 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Clone Nr. | (#8H46) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of INFa/b RI extracellular domain. |
| Antigen | recombinant human INF alpha/beta R1 EC domain |
| Application | WB, FC |
| Synonyms | IFNAR1; AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC; Interferon receptor |
| Uniprot ID | P17181 |
| Protein RefSeq | NP_000620.2 |
| mRNA RefSeq | NM_000629.2 |