human HVEM-Fc protein Human 20 µg

In stock

Cat-Nr.
SFC-040S
Size
20 µg
  €112.00

Description / human HVEM-Fc protein

HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta. Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.

More Information

Size 20 µg
Source Insect cells
Biological Activity Determined by its ability to neutralize 0.25 ng/ml of hTNFβ induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3-1.9 μg/ml of HVEM-Fc.
Purity Confirmation > 98% by SDS-PAGE & HPLC analyses
Length [aa] 376
Molecular Weight 41.4 kDa
Species Reactivity Mouse
Formulation lyophilized
Protein Sequence LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VV
Synonyms TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
Uniprot ID Q92956
Protein RefSeq NP_003811.2
mRNA RefSeq NM_003820.2

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