Follistatin-Related Gene Protein (FLRG) Anti-Mouse 100 µg

In stock

Cat-Nr.
103-M222
Size
100 µg
  €533.00

Description / Follistatin-Related Gene Protein (FLRG)

Follistatin-Related Gene Protein (FLRG), also known as follistatin-like 3 (FSTL3) is a glycoprotein belonging to the follistatin-module protein family. Mouse FLRG cDNA encodes a 256 amino acid (aa) residue protein with a putative 23 aa signal peptide, an N-terminal domain, two cysteine rich follistatin-like domains (FS) and a C-terminal acidic domain. Compared to follistatin, FLRG lacks the third FS domain found in follistatin. In addition, FLRG also lacks the heparin binding domain found within the first aminoterminal FS domain of follistatin. Mouse and human FLRG share approximately 83% aa sequence homology. Like follistatin, FLRG has been shown to bind and inhibit the activities of TGFβ family ligands including activin, BMP2, 6, 7, and GDF8/myostatin. While both FLRG and follistatin are located in a wide and overlapping range of adult and fetal tissue, their sites of peak expression differ: FLRG most highly in heart, lung, kidney, placenta and testis, while follistatin is highest in ovary and pituitary. The expression of FLRG is upregulated by TGFβ and activin signaling through Smad proteins. Although FLRG is a secreted protein in many cell types, it has also been localized to the nuclear compartment in HeLa, 293, and CHO cells.

More Information

Size 100 µg
Source Rat
Isotype IgG2
Clone Nr. (#7D11)
Species Reactivity Mouse
Formulation lyophilized
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant FLRG. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Antigen recombinant mouse FLRG
Application WB
Synonyms Fstl3; Flrg; E030038F23Rik
Uniprot ID Q62356
Protein RefSeq NP_032073.2
mRNA RefSeq NM_008047.5

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